Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. Acute asthma attack is one of the most common causes of visits to hospital emergency departments in all age groups of the population and accounts for the greater part of healthcare burden from the disease. Thank you for taking your time to send in your valued opinion to Science X editors. The researchers have uncovered a critical role for a protein (Caspase-11), which had previously never been implicated in the disease. We have found that Caspase-11 is a key driver of inflammation in the airways in asthma. May 26, 2020 June 13, 2020 TalkingAsthma 2 min read . Researchers from Trinity have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. Research can improve the quality of everyday life for those diagnosed with asthma. Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. (accessed December 12, 2020). Valve Surgery. Click here to sign in with Treat comorbid conditions. Breakthrough research breathes hope into a new treatment for asthma 19/08/2020 An international team of scientists, led by the Universities of Leicester and Glasgow, has announced findings that could pave the way to a new treatment for asthma and chronic obstructive pulmonary disease (COPD). The researchers have uncovered a critical role for a protein (Caspase-11), which had previously never been implicated in the disease. The severe form of the disease only affects about 5% of patients but is responsible for a large component of the overal … The content is provided for information purposes only. When this happens, it is likely to be a key driver of allergic inflammation in the lungs of asthmatics. Ireland has one of the highest incidences of asthma in Europe, which in its most severe form remains difficult to treat and can be fatal. You can be assured our editors closely monitor every feedback sent and will take appropriate actions. They report their findings today in leading journal Nature Communications. This document is subject to copyright. When this happens, it is likely to be a key driver of allergic inflammation in the lungs of asthmatics. Researchers make asthma breakthrough February 26, 2020 Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. 2019. The information you enter will appear in your e-mail message and is not retained by Medical Xpress in any form. Asthma is a pulmonary condition that causes the airways in your lungs to narrow and swell and produce additional mucus. ", Professor O'Neill said: "Caspase-11—or it's human equivalent, which is Caspase-4—has never been implicated in asthma before so we think it holds great promise as a possible target for new drugs to treat this common, debilitating disease.". Determinants of Acute Asthma Attack among adult asthmatic patients visiting hospitals of Tigray, Ethiopia, 2019: case control study. Researchers claim major breakthrough in ... New range of asthma treatments could be available within five years after medical breakthrough ... February 26, 2020 11:25 am. Source: https://medicalxpress.com/news/2020-02-asthma-breakthrough.html, Tips for Kids With Exercise-Induced Asthma, Best Exercises for Asthma: Yoga, Swimming, Biking, and Walking, https://www.nature.com/articles/s41467-020-14945-2, https://medicalxpress.com/news/2020-02-asthma-breakthrough.html, New Asthma Medicine Insights Could Improve Future Treatment, Air Quality Dramatically Impacts Health Outcomes. Get weekly and/or daily updates delivered to your inbox. For some patients, the effects are mild. Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. May 26, 2020 June 1, 2020 TalkingAsthma 1 min read . Breakthrough Drug Discovered For Asthma And COPD Treatment. Asthma research helps us understand how the disease is caused, how it develops and how it is best treated. Caspase-11 is a protein with an important role in defending against bacteria, but the team in Trinity has found that when it is over-active it can provoke a damaging inflammatory reaction. Last medically reviewed on March 31, 2020. Science X Daily and the Weekly Email Newsletter are free features that allow you to receive your favorite sci-tech news updates in your email inbox, Using 'the language of cells' to find new treatments for asthma, allergies, Researchers identify mouse brain pathways active during feelings of empathy, IPhone12 will stop your implantable defibrillator, Study explores the effects of morning weather on people's mood and wellbeing at work, Biotin, mitochondria, and dementia: Research reveals a connection, Study explores the effects of immune responses on the aging brain. As a result, your breathing becomes more difficult. Dr. Zaslona added: “A variety of irritants such as airborne pollutants, certain types of pollen and house dust mites can induce cell death in the lungs. Lead author Zbigniew Zaslona, working with a team led by Luke O’Neill, Professor of Biochemistry in the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute, has been exploring the role that inflammation plays in asthma—a very common and often serious disease of childhood. Although symptoms of mild asthma can be managed with current therapies, severe asthma remains very difficult to treat and asthma rates are constantly on the rise. We have found that Caspase-11 is a key driver of inflammation in the airways in asthma. or, by Trinity College Dublin. This causes the signs and symptoms of asthma which most notably involves difficulty breathing.”. Our work suggests that Caspase-11 is sensing these noxious things and causing disease.”, Professor O’Neill said: “Caspase-11—or it’s human equivalent, which is Caspase-4—has never been implicated in asthma before so we think it holds great promise as a possible target for new drugs to treat this common, debilitating disease.”. More in … asthma when there is a clear connection between symptoms and exposure to an allergen to which the patient is sensitive. 7 Incredible Health Breakthroughs Worth Celebrating in 2020 It was a devastating year in many ways, but 2020 also brought us life-changing developments. Consider allergic bronchopulmonary aspergillosis, gastroesophageal reflux, obesity, obstructive sleep apnea, rhinitis … Lead author Zbigniew Zaslona, working with a team led by Luke O'Neill, Professor of Biochemistry in the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute, has been exploring the role that inflammation plays in asthma—a very common and often serious disease of childhood. The finding brings hope to the 300 million asthma … Your opinions are important to us. The disease can be of various severity ranging from very mild to severe. Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma… Symptoms include: wheezing; shortness of breath From Principia Scientific International Website The Asthma Treatment That Is Beating COVID-19 Published on July 23, 2020 Written by Alan Gray Dr. Richard Bartlett, a Dallas MD who previously advised Governor Rick Perry for 7 years has a lifesaving COVID breakthrough, that Taiwan, Japan, Singapore and Iceland are also using. We do not guarantee individual replies due to extremely high volume of correspondence. They reported their findings in leading journal Nature Communications. The breakthrough is an inexpensive… Feature News . The researchers have uncovered a critical role for a protein (Caspase-11), which had previously never been implicated in … Neither your address nor the recipient's address will be used for any other purpose. This site uses cookies to assist with navigation, analyse your use of our services, and provide content from third parties. Although symptoms of mild asthma can be managed with current therapies, severe asthma remains very difficult to treat and asthma rates are constantly on the rise. Asthma is a chronic (long-term) condition that can cause the airways in the lungs to become inflamed and narrow. Your email address is used only to let the recipient know who sent the email. The researchers have uncovered a critical role for a protein (Caspase-11), which had previously never been implicated in the disease. Two amazing diabetes breakthroughs of 2020 The 2020 is being called a cursed year, thanks to the coronavirus outbreak, which is identified as the worst pandemic seen in over a century. Asthma breakthrough: potential cause and corrective treatment are identified. Researchers Make Asthma Breakthrough . 26th February 2020 26th February 2020 Researchers from Trinity have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. As the air sacs in your lung get larger, your lung can fill with too much air every time … The American Lung Association is committed to funding asthma research. Asthma, like other chronic conditions,… According to Asthma UK, 5.4 million people in the UK are currently receiving treatment for asthma: 1.1 million children (1 in 11) and 4.3 million adults (1 in 12). Breakthrough on diarrhea virus opens up for new vaccines by Umea University Illustration from cryo-electron microscope image of the enteric adenovirus HAdV-F41. A new double-combination therapy that promotes lung expansion and airway clearance has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of people with lung diseases including chronic obstructive pulmonary disease (COPD) and asthma. It may also trigger coughing, wheezing and/or shortness of breath. A breakthrough study has uncovered a potential root cause of asthma and a drug that reversed symptoms in lab tests. part may be reproduced without the written permission. Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. This causes the signs and symptoms of asthma which most notably involves difficulty breathing.". By Meryl Davids Landau Caspase-11 is a protein with an important role in defending against bacteria, but the team in Trinity has found that when it is over-active it can provoke a damaging inflammatory reaction. Harvard. Asthma is a chronic inflammatory disease of the airways affecting more than 300 million patients worldwide. By using our site, you acknowledge that you have read and understand our Privacy Policy Five per cent of people with asthma don't respond to current treatments so research breakthroughs could be life changing for hundreds of thousands of people. by Pooja Shete on January 9, 2021 at 1:22 PM Drug News. and Terms of Use. Dr. Zaslona added: "A variety of irritants such as airborne pollutants, certain types of pollen and house dust mites can induce cell death in the lungs. Our work suggests that Caspase-11 is sensing these noxious things and causing disease. National Prevalence of Asthma Attacks 1 among People with Current Asthma 2 by Age (2018) Characteristic Weighted number with asthma attack 1 Percent (SE) Total: 11,222,479: 45.4 (1.23) Child (Age <18 years) 2,965,929: 53.8 (2.70) Adult (Age 18+ years) 8,256,550: 43.0 (1.38) Researchers make asthma-Caspase-11 breakthrough February 26, 2020 ScienceBlog.com Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. Dr. Zaslona said: “Caspase-11 can cause cells to die, which is a very inflammatory event as the cells then release their contents, which can irritate tissues in our body. … Medically reviewed by Cynthia Cobb, DNP, APRN — Written by Stephanie Watson — Updated on March 31, 2020. This asthma and allergy breakthrough you are about to discover on this page has been scientifically verified and proven by doctors to reverse disease. Your feedback will go directly to Science X editors. The researchers have uncovered a critical role for a protein (Caspase-11), which had previously never been implicated in the disease. Daily science news on research developments and the latest scientific innovations, The latest engineering, electronics and technology advances, The most comprehensive sci-tech news coverage on the web. May 26, 2020 June 1, 2020 TalkingAsthma 438 Views 1 min read . You can unsubscribe at any time and we'll never share your details to third parties. Find more information in article, “Caspase-11 promotes allergic airway inflammation,” available at https://www.nature.com/articles/s41467-020-14945-2. Major asthma breakthrough as scientists discover root cause of the condition - and say a new treatment is less than 5 years away. The therapy was developed by the Monaghan Medical Corporation and combines two of their existing products — the … Researchers from Trinity College Dublin have made a breakthrough that may eventually lead to improved therapeutic options for people living with asthma. Learn about asthma causes, attacks, symptoms, risk factors, diagnoses, treatments, and NHLBI research and clinical trials. Asthma is a disease in which the airways swell up and tighten, making it hard to catch your breath. Researchers Make Asthma Breakthrough . Apart from any fair dealing for the purpose of private study or research, no For others, they are life-threatening. Bass, Kate. Dr. Zaslona said: "Caspase-11 can cause cells to die, which is a very inflammatory event as the cells then release their contents, which can irritate tissues in our body. The researchers have uncovered a critical role for a protein (Caspase-11), which had previously never been implicated in the disease. 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